Mazı (Zea mays L.) seedlings growth and activity dynamics of G6PDH (NADP-glucose-6-phosphate dehydrogenase), DMDH (NADP-malate dehydrogenase) and ISDH (NADP-isocitrate-dehydrogenase) enzymes have been studied under combined stress conditions created by NaCl and Na2SO4 salts solution. With regard to the development of seedlings (control), the activity of the G6PDH enzyme gradually decreases and this decrease in 12-day-old seedlings is 35.6% compared to 4-day-old seedlings. On the contrary, during this development phase, the activity of the DMDH and ISDH enzymes has increased by 37% and 13.4%, respectively in comparison with the initial period. This indicates that the formation of cytoplasmic NADPH potential in the early stages of the development of the Zagatala locally improved maize genotype seedlings is mainly done thanks to the activity of G6PDH enzyme, and in the later stages, mainly the activity of the DMDH and ISDH enzymes.