Hypokinesia exerts a significant effect on the hematological system of the organism. The aim of this study was to investigate leukocyte counts and key leukocyte indices in female rabbits subjected to hypokinesia during different stages of pregnancy and in their newborn offspring. The results demonstrated that changes in leukocyte numbers and leukocyte indices further confirm the role of inflammatory components. Specifically, an 85% increase in total leukocytes reflected a pronounced leukocytosis. Alongside this leukocyte elevation, lymphocytes increased by 75%, monocytes by 76%, and granulocytes by 62%, indicating activation of various immune cell populations. Both absolute values and relative proportions of these cells were notable. The relative proportion of lymphocytes rose by 42%, whereas monocytes decreased by 47% and granulocytes by 67%, highlighting a shift in leukocyte fraction distribution favoring lymphocytes. In pregnant rabbits experiencing hypokinesia at different gestational stages, this factor negatively impacted offspring viability, leading to reduced survival rates. These findings underscore the importance and relevance of investigating prenatal hypokinesia.