In the present work, a comprehensive study of natural compositions of medicinal plants growing in the territory of Azerbaijan was carried out in order to assess their antioxidant and antiradical activity. As the main analytical method, a model based on the ability of the investigated extracts to inhibit the stable free radical DPPH (2,2-diphenyl-1-picrylhydrazyl) was used, which makes it possible to quantitatively evaluate the efficiency of neutralizing radical oxygen species. During the experiment, aqueous-alcoholic extracts of various morphological parts of plants (roots, fruits, leaves, inflorescences) were used, which made it possible to compare biological activity depending on the localization of phytochemical compounds. The results of the study showed that extracts of medicinal plants selected from the flora of Azerbaijan demonstrate pronounced antioxidant and antiradical properties.The highest activity was observed in extracts from the roots of licorice (Glycyrrhiza glabra L.) and inflorescences of camelthorn (Alhagi pseudalhagi L.), which is confirmed by the minimal IC values in the neutralization of the DPPH radical, comparable to the activity of the standard antioxidant – vitamin E (Trolox). The obtained data confirm the expediency of further studies on the use of extracts from local medicinal plants as potential antioxidant agents in preventive and therapeutic practice.