This study investigates the ecological and geochemical characteristics of the southern slope of the Greater Caucasus and implements a regional zoning of the area. Ecological zoning has been carried out based on parameters such as soil types, vegetation cover, and climatic conditions. Geochemical zoning, in turn, has been conducted by analyzing the chemical composition of soils, the distribution of mineral resources, and the influence of geochemical processes. The results of the zoning provide critical insights into the sustainable use and conservation of natural resources across various landscape units within the region. The primary objective of the study is to enhance the understanding of the region’s ecological systems and to evaluate the impact of geochemical processes on these ecosystems. The findings may serve as a valuable basis for sustainable development strategies and effective natural resource management in the region.