Petroleum products are exposed to the environment, including atmospheric oxygen, numerous microorganisms, during transportation, storage and exploitation. These factors use the components of petroleum products as a reaction source and at the same time, interact with their transformation products, causing changes in their chemical composition. As a result, this reduces the operational qualities of petroleum products, making their effectiveness and long-term storage difficult. Considering the above, the antioxidant activity of (E,E)-3-(5-bromo-2-hydroxyphenyl)-1-(4-hydroxy-2 methylphenyl)prop-2-en-1-on thiosemicarbazone was determined based on the kinetic curves of cumene autoxidation. According to the obtained results, the rate coefficient (K7) of the reaction of the studied compounds with cumyl peroxide radicals, the stoichiometric coefficient of the induction period and the absorption kinetics of oxygen were determined. As a result of determining the induction period, it was found that the studied compound has high activity against oxidation and is more effective than the widely used 2,6-di-tert-butylphenol (ionol) in the industry.