One of the innovative methods for obtaining drug nanoparticles is the green synthesis method of metal-based nanoparticles in extracts from medicinal plants. When nanoparticles are synthesised in extracts of medicinal plants, there is a high probability of the biologically active molecules (drugs) contained in the extract being attached to their surface. The attachment of specific drug-active molecules to the surface of nanoparticles creates the possibility of using them as nanomedicines. In synthesising nanoparticles in plant extracts, the biologically active molecules in them act as both reducing agents and stabilizers.In the presented research materials, a comparative technology of synthesis of silver (Ag) nanoparticles in extracts of some medicinal plants (Melissa Lamiaceae, Rosmarinus officinalis, Achillea millefolium, Matricaria chamomilla) by thermal and sonication methods was developed. By comparing the absorption spectra of Ag nanoparticles synthesized by both the thermal method and the sonication method, it was comparatively studied which method synthesized Ag nanoparticles better. It was found that the sizes of Ag nanoparticles vary depending on the dose of extracts in the synthesis by both methods. In the sonication method of nanoparticles, the sizes of nanoparticles depend on both the sonication time and the dose of extracts.