The search and prediction criteria for the discovery of promising areas for endogenous mineralization within the Murovdag-Aghdam uplift were considered in the article. It was determined that the location of ore deposits and occurrences in the regional plan is subject to the location of the main tectonic elements in the general structure of the region and the presence of deep faults demarcating separate blocks. The prospect of discovering copper-gold-pyrite, copper-polymetallic, copper-porphyry, copper-pyrite and other types of deposits and occurrences within the Murovdag and Agdam uplifts is characterized by the extensive development of products of Jurassic volcanism, and these mineralizations are genetically and spatially related to sour differentiates. The deposits and occurrences of the region are adapted to horst blocks, characterized by strong shear-faults, permeability of hydrothermal solutions, development of thick volcanogenic series rocks, presence of volcanic centers, volcano-dome structures and vent structures. Mineralizations are spatially located in the endo- and exotopic of intrusive complexes, in the contact zone between their separate phases, and in intensively fractured gabbro-diorite, quartz diorite massifs, and in the dyke mass associated with the intrusive. Mineralizations are spatially located in the endo- and exocontact of intrusive complexes, in the contact zone between their separate phases, and in intensively fractured gabbro-diorite, quartz diorite massifs and in the dyke mass associated with the intrusive. It was determined that the analysis of the morphostructural features of the region, the genetic or paragenetic relationship of mineralization with igneous rocks, paleogeographical and geomorphological analyses, the development and selection of search-preticted criteria, signs and methods of mineralization, and all regularities that have affected the spatial location of deposits should be taken into account for the metallogenic prediction of ore regions, areas and deposits and the assessment of potential mineralization.