This article provides an extensive analysis of the significance and application prospects of integrative approaches characterizing new instructional methods in chemistry education. It explains that in the modern education system, the implementation of innovative teaching methods, particularly integrative approaches, plays a crucial role in facilitating interdisciplinary integration and allowing students to comprehend topics in a broader and deeper context. The article explores how these approaches in chemistry teaching effectively enhance students’ theoretical and practical knowledge. The focus is on contemporary teaching methods such as Problem-Based Learning (PBL), Project-Based Learning (PjBL), cooperative learning, the use of digital technologies, and practical laboratory work. These methods have significant potential to develop students' critical and analytical thinking skills, making learning more engaging and meaningful by confronting them with real-life problems. The ability of teachers to implement these new methods and their role in the teaching process is a central theme of the article. Additionally, the use of digital resources in the teaching process, the adaptation of teaching materials to the integrative approach, and the development of infrastructure are thoroughly discussed. The challenges encountered in applying integrative teaching approaches and ways to overcome them are also analyzed. The article also presents examples of new teaching methods successfully implemented in various parts of the world. The article concludes that integrative approaches in chemistry education make a significant contribution to the learning process and are vital tools for improving the quality of education. The widespread application of these approaches is important for enriching students' learning experiences and fostering the development of scientific thinking.